The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

September 23rd, 2019 by Amalie F. Rudolf

Nature Chemical Biology, Published online: 23 September 2019; doi:10.1038/s41589-019-0370-y

Cholesterol can function as both a substrate and an inhibitor of the Hedgehog receptor Patched. Structural analysis and molecular dynamics simulations reveal that cholesterol inhibits Patched by inserting into its extracellular domain
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