The Regulation of Synaptic Protein Turnover [Protein Synthesis and Degradation]

October 9th, 2015 by Alvarez-Castelao, B., Schuman, E. M.

Emerging evidence indicates that protein synthesis and degradation are necessary for the remodeling of synapses. These two processes govern cellular protein turnover, are tightly regulated, and neuronal activity modulates them in time and space. The anisotropic anatomy of the neurons presents a challenge for the study of protein turnover, but understanding protein turnover in neurons and its modulation in response to activity can help us to unravel the fine-tuned changes that occur at synapses in response to activity. Here we review the key experimental evidence demonstrating the role of protein synthesis and degradation in synaptic plasticity, and the turnover rates of specific neuronal proteins