2-Hydroxyacyl-CoA lyase catalyzes acyloin condensation for one-carbon bioconversion

August 5th, 2019 by Alexander Chou

Nature Chemical Biology, Published online: 05 August 2019; doi:10.1038/s41589-019-0328-0

A bacterial 2-hydroxyacyl-CoA lyase catalyzes ligation of carbonyl-containing molecules of different chain lengths with formyl-CoA to produce elongated 2-hydroxyacyl-CoAs, enabling a one-carbon bioconversion pathway with formaldehyde as a substrate.
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