Biosynthesis: Methylating mushrooms

July 18th, 2017 by Albert A Bowers

Nature Chemical Biology 13, 821 (2017). doi:10.1038/nchembio.2437

Author: Albert A Bowers

The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.