The substrate lends a hand

September 17th, 2018 by Albert A. Bowers

The substrate lends a hand

The substrate lends a hand, Published online: 17 September 2018; doi:10.1038/s41589-018-0135-z

Duramycin is a small post-translationally modified peptide with antibody-like affinity for phosphatidylethanolamine. As it turns out, the same functionality that is essential for duramycin activity helps to catalyze the formation of its conformationally constrained and compact polycyclic architecture.