TAGing for destruction

March 26th, 2018 by Aisha Yesbolatova

TAGing for destruction

TAGing for destruction, Published online: 26 March 2018; doi:10.1038/s41589-018-0024-5

Proteins brought to an E3 ubiquitin ligase are polyubiquitylated for rapid degradation via the proteasome. A new study developed a tag-based degradation system using heterobifunctional degradation inducers called dTAGs, which rapidly depleted FKBP12F36V-fused proteins in cultured cells and in mice.