Allostery governs Cdk2 activation and differential recognition of CDK inhibitors

February 1st, 2021 by Abir Majumdar

Nature Chemical Biology, Published online: 01 February 2021; doi:10.1038/s41589-020-00725-y

Dissection of the allosteric coupling in the cyclin-dependent kinase Cdk2 shows that this allostery explains how the kinase is activated by cyclin binding and phosphorylation and how it differentiates between Cdk2 and Cdk4 inhibitors.
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