Biosynthesis: Leading the way to RiPPs

July 21st, 2015 by A James Link

Nature Chemical Biology 11, 551 (2015). doi:10.1038/nchembio.1862

Author: A James Link

Many peptide-based natural products require a leader peptide to reach their final modified form, but the identification of general rules for leader peptide interactions have been stymied by the diversity of these molecules. Two papers reporting crystallographic and bioinformatic analysis of these systems now reveal a structurally conserved domain that mediates leader peptide binding.